Peer Reviewed

Identification by Quantitative Carrier Test of Surrogate Spore-Forming Bacteria To Assess Sporicidal Chemicals for Use against Bacillus anthracis: Miles R. Majcher, Kathryn A. Bernard, and Syed A. Sattar
The spores of six strains of Bacillus anthracis (four virulent and two avirulent) were compared with those of four other types of spore-forming bacteria for their resistance to four liquid chemical sporicides (sodium hypochlorite at 5,000 ppm available chlorine, 70,000 ppm accelerated H2O2, 1,000 ppm chlorine dioxide, and3,000 ppm peracetic acid).
Excerpt:“The sporicidal activity of a given formulation is only one among a set of features to be considered in dealing with any decontamination scenario. Human and environmental safety, as well as materials compatibility, are among the other factors to keep in mind. Though bleach is fast acting, inexpensive, and generally readily available, its main drawbacks are off-gassing inactivation in the presence of organic loads and high corrosivity. In contrast, AHP-based formulations are reasonably fast acting and also have much-higher materials compatibility, while being less toxic to humans and the environment (8).”
Risk of Hand or Glove Contamination After Contact With Patients Colonized With Vancomycin-Resistant Enterococcus or the Colonized Patients’Environment: Mary K. Hayden, MD; Donald W. Blom, BSN; Elizabeth A. Lyle, AB; Charity G. Moore, PhD; Robert A. Weinstein, MD
Recently published data suggests that the inanimate environment serves as a reservoir for VRE transmission in Hospitals.
Excerpt:“HCWs make an average of 7 environmental or patient contacts per episode of care with a higher rate of hand contamination with HCWs that touched both the environment and the patient resulting in a 10% risk of hand contamination for every contact. 21% of the HCWs entering the room had VRE contamination on their hands prior to patient care. HCWs wearing gloves were less likely to contaminate their hands than those who did not wear gloves (37% vs 5%). HCWs performing patient care were as likely to contaminate their hands after touching an environmental surface as they were touching both the patient and the environment (52% vs 70%).”
Viruses as Nosocomial Pathogens: The Environmental Connection (613 KB): Syed A. Sattar, Ph.D. Professor of Microbiology Centre for Research in Environmental Microbiology (CREM) Faculty of Medicine, University of Ottawa.
Excerpt:“"Proper use of microbicides in hospitals lowers the risk of acquiring a nosocomial infection by reducing the pathogen load. Microbicides (disinfectants) can also interrupt pathogen transfer from contaminated to clean surfaces"”
Current Issues in testing, selection and use of microbicides in infection control: a critical review (5.20 MB): Syed A. Sattar, Ph.D. Professor of Microbiology Centre for Research in Environmental Microbiology (CREM) Faculty of Medicine, University of Ottawa.
This article highlights approaches to developing better ways of testing microbicides and the potential dangers of microbicide use in the workplace and the factors to consider in the selection and application of such formulations to optimize safety and effectiveness in the field
Hydrotherapy Tub Usage (1.76 MB): Canadian Nursing Home
An Accelerated Hydrogen Peroxide-Based Fast-Acting and Reusable Microbicide for Manual Disinfection of Heat-Sensitive Semi-Critical Medical Devices (983 KB): Navid Omidbakhsh, B.Sc., Nicole Kenny, B.Sc., Assoc Chem
The focus of this study was to assess the antimicrobial activity, stability and materials compatibility of a newly-developed AHP-based high level disinfectant in simulated reuse conditions.
Excerpt:“The AHP-based formulation evaluated here remained a broad-spectrum and fast acting microbicide even after 14 days of simulated reuse.” pg. 5
Hydrotherapy Tub Usage (Infection Risks - Cleaning and Disinfecting) (1.76 MB): Bernice Thompson, R.N., B.N., E.T. and Scott Budgell, B.Sc., CPHI(C)
Excerpt:“after weeks of trialing various products and making comparisons with other chemical disinfectants, opted for the use of an Accelerated Hydrogen Peroxide compound. This product has been found to have advantages over other chemical cleaners and disinfectants in a number of areas including disinfection capabilities, efficiency in cleaning and cost effectiveness.” pg. 9
Products Based on Accelerated and Stabilized Hydrogen Peroxide: Evidence for Cleaning and Sanitizing Efficiency, Environmental and Human Safety and Non-Corrosiveness (1.52 MB): Michael Rochon and Nancy Sullivan
Products sold under Virox 5, Percept, Accel, Peroxigard
Combined application of simulated reuse and quantitative carrier tests to assess high-level disinfection: experiments with an accelerated hydrogen peroxide-based formulation (151 KB): Syed A. Sattar, Ph.D. Professor of Microbiology Centre for Research in Environmental Microbiology (CREM) Faculty of Medicine, University of Ottawa.
Excerpt:“AHP product (sold under Accel CS 20) represents an alternative to glutaraldehyde with enhanced material compatibility and demonstrates broad-spectrum germicidal activity of a high-level disinfectant subjected 14 days of reuse”
A New Hydrogen Peroxide - Based Medical-Device Detergent With Germicidal Properties: Comparison With Enzymatic Cleaners (168 KB): Michelle J. Alfa, PhD Michele Jackson, BScb Detroit, Michigan, and Winnipeg, Manitoba, Canada
Excerpt:“KDS has excellent microbial-killing ability in 3-minute exposures and cleans as well as existing enzymatic detergent formulations that were tested and provides a greater protection to HCW's” pg. 168
A Product based on accelerated and stabilized hydrogen peroxide: Evidence for broad-spectrum germicidal activity (406 KB): Syed A. Sattar, PhD and V. Susan Springthorpe, M.Sc.
Excerpt:“Accelerated Hydrogen Peroxide (AHP) contains ingredients which are considered safe for humans & benign to the environment. This product has superior cleaning power and increased germicidal potency and has numerous potential applications where cleanup & disinfection are crucial. The product diluted at 1:16 can be used as a general purpose disinfectant (products sold under Virox 5, Percept, Accel, Peroxigard)” pg. 6 & 7
Activity of selected oxidizing microbicides against the spores of Clostridium difficile: Relevances to Environmental Control (172 KB): Syed A. Sattar, Ph.D. Professor of Microbiology Centre for Research in Environmental Microbiology (CREM) Faculty of Medicine, University of Ottawa
Excerpt:“AHP-based technology has been gaining acceptance as a means of formulating safer and environmentally benign microbicides with activity against major classes of nosocomial pathogens. Virox STF could inactivate C difficile spores on hard environmental surfaces in approximately 10-15 minutes under ambient conditions (product sold under Accel CS 20)" ” pg. 5
Broad-spectrum microbial activity, toxicologic assessment, and materials compatibility of a new generation of accelerated hydrogen peroxide-based environmental surface disinfectant (117 KB): N. Omidbakhsh, B.Sc, Virox Technologies Inc.
Excerpt:“Accel TB (also sold under Oxivir TB, Optim 33TB, Carpe Diem TB) showed a high safety and materials compatibility profile in addition to being a fast acting, intermediate-level disinfectant” pg. 1
A new peroxide-based flexible endoscope-compatible high-level disinfectant (94 KB): N. Omidbakhsh, B.Sc, Virox Technologies Inc.
Excerpt:“AHP-based high-level disinfectant (Accel HLD 5) proved to be a broad spectrum microbicide, fast acting and safer to end users and the environment and is considered compatible with flexible endoscope” pg. 6
Is skin irritancy of the hand wash products solely related to their pH? (1.52 MB): P. Grasha, PhD, Deb Group, N. Omidbakhsh, B.Sc, Virox Technologies
Excerpt:“pH must not be the only criteria used to predict the potentially irritant character of a cosmetic preparation. Other ingredients used in the formulation have intrinsic irritating power independent of pH such as chemical structure or concentration” pg. 5